Researchers used a failed weight-loss medication to prevent heat stroke in mice. AICAR prevented death from heat stroke in mice genetically altered to have a RYR1 mutation, the gene responsible for causing malignant hyperthermia. All mice treated with the drug survived heat stroke. Researchers hope the drug's use will extend beyond people who also have the RYR1 mutation for malignant hyperthermia and help all people who suffer from heat stroke.
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