H2 receptor antagonists safer than PPI for stress ulcer prevention

01/17/2014 | Medscape (free registration)

Critically ill patients who received proton pump inhibitors for stress ulcer prophylaxis were significantly more likely to suffer adverse events such as gastrointestinal bleeding and 30-day mortality than those who received histamine 2 receptor antagonists, according to a study presented at the SCCM Critical Care Congress. The PPI group also had a slightly higher risk of nosocomial pneumonia and Clostridium difficile infection than those who took H2 receptor antagonists.

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