Enzyme helps pathogens enter cells, mice study finds

01/19/2012 | Lantern (Ohio State University), The

Ohio State University researchers found that mice lacking PI3K gamma, an enzyme that recruits white blood cells to the site of infection, are resistant to infection from certain parasites, including leishmaniasis, a tropical disease of animals and humans transmitted by sand flies. The hypothesis now being tested is that certain pathogens take advantage of the enzyme's function, using it to enter cells and cause infection. If the mechanism of entry into the cell is blocked, the pathogen cannot cause disease.

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Lantern (Ohio State University), The

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