Study: 18F-ISO-1 PET effective at imaging cycling cancer cells

01/29/2013 | MolecularImaging.net

PET scans using 18F-ISO-1 in patients with newly diagnosed primary breast cancer, head and neck cancer or lymphoma showed significant correlation between uptake of tumor Ki-67, a marker for cancer cell proliferation, and 18F-ISO-1 in terms of tumor-to-muscle activity ratios and maximum standard uptake value, according to a study in the Journal of Nuclear Medicine. "The high correlation of tumor-to-muscle ratio with Ki-67 scores indicates that F18-ISO-1 may provide an imaging alternative to biopsy specimens for obtaining this measurement," researchers said. The method may also be useful in identifying patients likely to respond to treatments against cycling cancer cells, they added.

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