Scientists from East China Normal University and Tongji University have modified gold nanostructures to deliver drugs to cancer cells without harming normal cells by adding a peptide known as A54. The researchers tested the approach on human liver cancer cells, finding the gold nanoshells plus doxorubicin and A54 had greater uptake than the nanoshells with the anticancer drug but no A54. There was also less uptake of both by healthy cells. The gold nanoshell structure also might allow for conversion of near-infrared light into heat, improving hyperthermia treatment. Details of the study appear in the journal Biomedical Materials.
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