Gene deficiency linked to fungal infection risk after stem cell transplant

02/18/2014 | Healio (free registration)

Patients who receive hematopoietic stem cells from donors with PTX3 gene deficiencies may have an increased risk of developing aspergillosis, according to a study in The New England Journal of Medicine. An analysis of data involving 268 patients and their donors found that receipt of a transplant from a donor with a homozygous haplotype in the PTX3 gene was associated with greater risk of infection and also was linked to impaired PTX3 expression. The PTX3 deficiency affects the function of neutrophils.

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