Genetic mutation may disable fat sensors, raise obesity risk

02/19/2012 | eMaxHealth.com

Mice carrying a genetic defect making them deficient in the fat-sensing GPR-120 protein gained more weight and developed higher fasting plasma glucose and insulin levels than their normal wild type counterparts when fed a high-fat diet, a study in Nature found. An analysis in humans showed one particular mutation in the gene sequence coding for GPR-120 disables its fat-sensing capabilities, resulting in a 60% increase in obesity risk, researchers said.

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