Gladstone Institutes and University of California, San Francisco, researchers have developed a method of reprogramming skin cells into functioning liver cells, according to a study in the journal Nature. Skin cells were reprogrammed into endoderm-like cells using a cocktail of genes and molecules. A new set of genes and molecules was then used to turn those cells into functioning liver cells that were transplanted into the failing livers of mouse models. After two months, an increase in human liver protein levels demonstrated that the cells had matured, and the growth had not stopped through nine months.
Scientists reprogram skin cells into functioning liver cells
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