Peptide may usher nanoparticles past immune system into tumors

02/25/2013 | Nature (free content)

University of Pennsylvania researchers have designed molecules bearing a segment of the membrane protein CD47, which tricks macrophages into allowing drug-bearing nanoparticles into blood cells, according to a study published in Science. The researchers designed a 21-amino-acid peptide based on the CD47 sequence and attached it to polystyrene nanobeads that also included a dye that can be identified using fluorescence spectroscopy. Tests on mice showed the nanobeads sneak past immune cells and accumulate in tumors. Researchers hope the technique can be improved to employ customized nanobeads.

View Full Article in:

Nature (free content)

Published in Brief:

SmartBrief Job Listings for Health Care

Job Title Company Location
Consultant
Attest Health Care Advisors
Nationwide, SL_Nationwide
Biotechnology/Pharmaceutical Patent Attorney
Coats and Bennett PLLC
Cary, NC
Sr. Regulatory Specialist, Biotech Center of Expertise
BASF, The Chemical Co.
San Diego, CA
Food Lawyer
Cargill
Wayzata, MN
Actuary
Meridian Health Plan
Detroit, MI