PPIs may raise risks for ventilated patients, study says

02/25/2014 | Medscape (free registration)

An observational study in JAMA Internal Medicine suggested proton pump inhibitor therapy for mechanically ventilated patients may raise the risk of gastrointestinal bleeding, pneumonia and Clostridium difficile infection, when compared with a histamine-2 receptor antagonist. The drugs are commonly used as a stress ulcer prophylaxis in ICU patients, and researchers said more studies are needed before recommending a change in practice.

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