Pediatric patients with severe aplastic anemia were able to tolerate and benefit from haploidentical hematopoietic stem cell transplants, according to a study published in Biology of Blood and Marrow Transplantation. Eleven of the 12 patients who underwent the treatment showed neutrophil engraftment at a median of 10 days following the transplant, researchers said. In one primary engraftment failure case and two graft rejection cases, a second haploidentical hematopoietic stem cell transplant led to a 100% final engraftment rate, the study said. Follow-up at a median of 14.3 months showed all 12 patients were alive and no longer requiring transfusions.
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