Study finds age-dependent gene expression differences with autism

03/25/2012 |

Researchers examined postmortem brain samples of 33 patients and found those with autism ages 2 to 14 had abnormalities in pathways responsible for cell number, cortical patterning and differentiation, while autism patients ages 15 to 56 had abnormalities affecting signaling and repair. The DNA extracted from the prefrontal cortex showed autism-specific copy number variations in genes responsible for cell cycle regulation. The study appears in the journal PLoS Genetics.

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