Animal study suggests utility of PET for Menkes disease

03/26/2014 | AuntMinnie.com (free registration)

Japanese researchers used PET with copper-64 to track and visualize the effects of treatment for Menkes disease, a rare condition in which patients are unable to absorb copper. After researchers injected mouse models with the isotope along with either disulfiram or D-penicillamine, PET showed higher copper uptake in the brain and reduced uptake in the kidneys in the disulfiram group compared with those treated with copper alone. The results published in the Journal of Nuclear Medicine suggest the efficacy of the drug in increasing copper uptake in the brain and the potential of PET for guiding development of Menkes disease treatment.

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