The transition from acute to chronic pain

03/26/2014 | Journal of Pain, The

Hyperalgesic priming, a model of the transition from acute to chronic pain produced by a prior inflammatory insult, is expressed as a long-lasting neuroplastic state in which there is enhanced hyperalgesia induced by pronociceptive cytokines. This work demonstrates that the mechanisms previously shown to induce the neuroplastic state of hyperalgesic priming also mediate the prolongation of hyperalgesia. The data provided by this study suggest that direct intervention on specific targets may help to alleviate the expression of chronic hyperalgesic conditions.

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