Scientists identify molecular spigot in insulin-resistant diabetes

04/9/2012 | Yahoo!

A molecular receptor, IP3, on the outside of cells in the liver acts with another molecule, calcineurin, to stimulate the CRTC2 genetic switch, resulting in excessive blood glucose levels in patients with insulin-resistant type 2 diabetes, researchers report in Nature. The findings suggest inhibiting the IP3 spigot and calcineurin activity may help stop the CRTC2 switch and better regulate blood glucose levels.

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