Engineered gut bacteria improves type 1 diabetes in mice

04/10/2012 | Genetic Engineering & Biotechnology News

Lactococcus lactis that was engineered to secrete whole proinsulin autoantigen and immunomodulatory human cytokine IL-10 stabilized blood glucose levels and suppressed diabetes-related autoantigen responses when fed to non-obese mice with type 1 diabetes, according to a study in the Journal of Clinical Investigation. L. lactis-anti-CD3 therapy appeared to reactivate beta cells and may only be successful when there is an adequate number of potentially functional cells, researchers said.

View Full Article in:

Genetic Engineering & Biotechnology News

Published in Brief:

SmartBrief Job Listings for Health Care

Job Title Company Location
Counsel – Regulatory Affairs
RAI Services Company
Winston Salem, NC
Director of Program Development
Washington DC, DC
Director of System QA
LifeWatch Services, Inc.
Rosemont, IL
Director of Business Development and Membership
Washington DC, DC
Director, Corporate Counsel
Tarrytown, NY