Genetically altered stem cells produce HIV-resistant cells

06/10/2014 | (U.K.)

A team of scientists from the University of California have used the CRISPR-Cas9 gene-editing tool to alter induced pluripotent stem cells in an effort to replicate the protective CCR5 mutation in CD+4 T cells and boost the immune system to fight off HIV. However, the team ended up generating a white blood cell resistant to HIV. Researchers now speculate that instead of creating an HIV-resistant white blood cell, they could create HIV-resistant stem cells that, when transplanted into the body, would give rise to all cell types found in the blood.

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