PET with FDDNP detects plaque in patients with Down syndrome

06/13/2011 | EurekAlert!

PET using the FDDNP chemical marker revealed higher binding levels of amyloid plaques and neurofibrillary tangles in patients with Down syndrome in all brain areas when compared with healthy subjects, according to a study published in the Archives of Neurology. Patients with Down syndrome also showed higher binding levels in the parietal and frontal regions, which influence cognitive function, compared with patients with Alzheimer's disease. "Neuroimaging may be a helpful tool in assessing and tracking plaque and tangle development over time in this population," senior study author Dr. Gary Small said.

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