Inhibiting key molecule boosts insulin response in mice, study finds

07/6/2011 | Augusta Chronicle (Ga.), The

A study in Cell Metabolism found that mice lacking the heat shock transcription factor-1 molecule had improved insulin sensitivity, gained less weight and did not develop fatty liver when fed a high-fat diet. "The big challenge for us as scientists is how we can modify this molecular chaperone to affect particular pathways without involving [it] in the disease progression, without affecting other housekeeping functions of the molecule," Dr. Demetrius Moskophidis, a professor at Georgia Health Sciences University.

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Augusta Chronicle (Ga.), The

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