Thiazide use and hyponatremia

07/9/2013 | American Journal of Kidney Diseases

Hyponatremia may be associated with increased risk of death and more subtle changes, including decreased physical and cognitive performance. The authors analyzed the prevalence of and risk factors for thiazide-associated hyponatremia in the adult general population. They found that thiazide use was associated with a fivefold increased risk of mild hyponatremia and eightfold increased risk of moderate and severe hyponatremia; younger age and lower body mass index were associated with hyponatremia. Accordingly, monitoring serum sodium levels in thiazide-treated patients is recommended.

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American Journal of Kidney Diseases

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