2 pathologies could explain early memory issues, researchers say

07/14/2013 | MedPage Today (free registration)

Data from the Harvard Aging Brain Study suggest that some patients who pass standard cognition tests and do not carry significant levels of beta amyloid may still show signs of neuronal dysfunction. The study used PET scans with the Pittsburgh Compound B tracer to assess beta-amyloid protein buildup in a number of participants, while FDG-PET scans were used to evaluate neuronal metabolic activity. Researcher Dorene Rentz recommended further imaging studies measuring tau protein tangles and other aspects of Alzheimer's disease to support their hypothesis that two pathologies may be involved in the development of Alzheimer's.

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