Weimaraner genome gives clues to human neural tube disorders

07/22/2013 | MedicalDaily.com

Researchers at the University of California, Davis, School of Veterinary Medicine found a gene mutation in Weimaraners associated with spinal dysraphism in dogs that may help scientists better understand neural tube defects in humans. The genomes of four Weimaraners with spinal dysraphism were analyzed, as were the genomes of 96 Weimaraners with no spinal abnormalities. The gene NKX2-8 on chromosome eight, part of a group of genes known to cause developmental defects, mutated in a specific way in Weimaraners that were affected with the neural tube problems.

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