Scientists at Canada's McGill University and Genome Quebec Innovation Centre have described a new technique for analyzing DNA at the genomic and single-molecule level using DNA from a single cell. McGill's Sabrina Leslie and her colleagues introduced tunable nanoscale confinement to capture molecules in a way that allows for optical analysis. The method is called convex lens-induced nanoscale templating. "Once these long strands of DNA are gently squeezed down into nanochannels from a nanoscale bath above, they become effectively rigid which means that we can map positions along uniformly stretched strands of DNA, while holding them still," Leslie said.
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