Case study points to safety of Alzheimer's prevention strategy

Drugs that reduce, eliminate or neutralize the effects of the apolipoprotein E gene might succeed in preventing the symptoms of Alzheimer's disease without hurting brain function, researchers report in the journal JAMA Neurology. Studies showed that a man who lacks the APOE gene has normal brain function, suggesting that anti-APOE therapies for Alzheimer's would not cause neurological side effects. Proteins made by APOE4 slow the clearing of beta-amyloid in the brain and allow the accumulation of plaques associated with Alzheimer's, researchers say.

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