Patients with early-stage Parkinson's disease had lower levels of beta-amyloid protein AB42, total tau protein, P-tau protein and alpha-synuclein in their cerebrospinal fluid than healthy controls, all of which are associated with motor disturbances in Parkinson's disease. The four proteins "have prognostic and diagnostic potential in early-stage Parkinson's disease, [and] suggest biomarker strategies for the possible recognition of prodromal Parkinson's disease," the researchers write in JAMA Neurology.
Study links low cerebrospinal fluid proteins with early Parkinson's disease
SmartBrief Job Listings for Health Care
|Senior Director, Biostatistics||
|Associate - Food and Drug||
Keller and Heckman LLP
|Senior Paralegal - Research & Development, and Medical||