Study links low cerebrospinal fluid proteins with early Parkinson's disease

08/29/2013 | MedPage Today (free registration)

Patients with early-stage Parkinson's disease had lower levels of beta-amyloid protein AB42, total tau protein, P-tau protein and alpha-synuclein in their cerebrospinal fluid than healthy controls, all of which are associated with motor disturbances in Parkinson's disease. The four proteins "have prognostic and diagnostic potential in early-stage Parkinson's disease, [and] suggest biomarker strategies for the possible recognition of prodromal Parkinson's disease," the researchers write in JAMA Neurology.

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