Mouse study holds clues to disorders in children of older dads

08/31/2011 | MSNBC

Children of older fathers are more likely to be diagnosed with autism, schizophrenia and other disorders that apparently stem from gene mutations, say researchers whose work with mice revealed gene mutations that led to subtle brain changes in offspring of older male mice. Mouse and human genomes are about 85% identical. "Mice do not get schizophrenia or autism. But, we have found previously that the offspring of older mice have subtle changes in brain structure and behavior," said senior study author John McGrath.

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