Scientists shed light on heart disease cases in HRT study

09/16/2007 | Wall Street Journal (free content), The

A compound called 27-hydroxycholesterol -- a byproduct created as the body processes cholesterol -- can block estrogen from performing functions in blood vessels that prevent heart attacks, thus clarifying why hormone-replacement therapy conducted during the Women's Health Initiative study failed to prevent heart disease in selected patients, researchers report. The finding is the latest in a series of studies focused on why some women in the controversial trial were found to be at high risk for heart disease.

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Wall Street Journal (free content), The

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