Children with Down syndrome have leukemia-causing gene mutation

Having mutations in the GATA1 gene can put children with Down syndrome at risk of developing a myeloid proliferation problem called transient abnormal myelopoiesis, Japanese researchers said. They found that children with Down syndrome who developed acute megakaryoblastic leukemia had additional alterations in other possible driver genes, including those in epigenetic and signaling pathways. The findings appear in the journal Nature Genetics.

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