Human chromosome transplant may yield insight into Down syndrome

09/27/2005 | Boston Globe (tiered subscription model), The

Researchers report success in transplanting most of a human chromosome into mice, a development they believe could lead to better understanding and possible cures for genetic disorders such as Down syndrome. The chromosome was removed from human cells, mixed with mouse embryonic stem cells and injected into mice embryos, which were re-implanted into the mothers. The mice show features of Down syndrome because they absorbed an extra copy of chromosome 21.

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