Chromatic profiling reveals gene mutation in childhood acute lymphoblastic leukemia

09/30/2013 | GenomeWeb Daily News (free registration)

Researchers assessed chromatin patterns in pediatric acute lymphoblastic leukemia patients with the histone 3 lysine 36 dimethylation signature and found a mutation in the methyltransferase enzyme-coding gene called NSD2. The findings, published in the journal Nature Genetics, suggest that chromatin profiling is a promising tool for detecting genetic mutations with unknown epigenetic consequences.

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