Study: GSK-3 inhibitors may cause congenital heart problems

10/3/2008 | Yahoo!

U.S. scientists working on mice genetically engineered to lack two forms of glycogen synthase kinase-3 reported data indicating that a new class of medicines that targets the protein may increase congenital heart problems. In the study, mice without GSK-3-alpha were born with normal hearts, but those that lacked GSK-3-beta died before birth -- mostly at late gestation -- because of several heart defects, including unusually thick cardiac muscle because of overdevelopment.

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