Study: SSRI, NSAID combo increases GI bleeding

10/10/2007 | United Press International

The combined use of selective serotonin reuptake inhibitors and nonsteroidal anti-inflammatory drugs to treat depression and other illnesses may heighten the risk of gastrointestinal bleeding by more than 600%, researchers warned. Data from four studies involving 153,000 patients showed that GI bleeding occurred after an average of 25 weeks in patients who took SSRIs, 67% of whom were also taking NSAIDs.

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