Genetic variation in GATA3 tied to increased risk of childhood lymphoblastic leukemia

11/5/2013 | Oncology Nurse Advisor online

Children who inherited a high-risk variant in the GATA3 gene were almost four times more likely to develop Philadelphia chromosome-like acute lymphoblastic leukemia than those with a different genetic variation, a study in the journal Nature Genetics showed. The high-risk gene variant was also associated with poor treatment response as well as increased recurrence risk.

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