Researchers develop microchip lung that mimics pulmonary edema

11/8/2012 | Mass High Tech (Boston)

A "lung-on-a-chip" technology that imitates the effects of pulmonary edema, including fluid barrier functions and human oxygen transport, was developed by researchers at Harvard University's Wyss Institute for Biologically Inspired Engineering. "[F]or the first time we demonstrate that we can model a complex human disease on an organ chip lined with human cells -- in this case pulmonary edema -- and that we can use it both to identify relevant drug toxicities, and to screen for new drugs that prevent this response," lead scientist Geraldine Hamilton said. One of the project's goals is to eliminate the use of animals in trials of experimental drugs for lung disorders.

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