Trial compares different doses of Merck's Zocor

11/9/2008 | Reuters

Scientists at the University of Oxford in the U.K. found that 80-mg doses of simvastatin, sold by Merck & Co. as Zocor, lowered "bad" LDL cholesterol by about 14% more than 20-mg doses during an average 6.7 years of treatment. Although researchers concluded that high-dose Zocor was safe, it was linked to 53 cases of myopathy, a muscle-weakening illness, compared with three patients who took lower doses.

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