Plaques after brain injury identified with PiB-PET imaging

PET imaging with Pittsburgh Compound B revealed amyloid plaques in the brain can form within hours of traumatic brain injury, according to researchers from the University of Cambridge. When postmortem scans of 15 patients with TBI were taken and compared with 11 healthy controls, researchers saw increased PiB distribution in regions of the brain associated with memory, suggesting amyloid plaque buildup that could lead to an early Alzheimer's-like effect. The study, which appeared in JAMA Neurology, also showed the potential utility of PiB-PET for studying TBI's long-term effects.

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