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Prepubertal obese youths may benefit from metformin

Prepubertal obese children who took metformin had lower body mass index z-scores as well as better inflammatory and cardiovascular-related obesity parameters after six months, compared with those who received placebo, Spanish researchers reported in Pediatrics. However, the findings, based on data involving 160 Spanish youths ages 7 to 14, didn't show benefits in pubertal youths who received the drug.

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