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Biomarker-based screening could ID monogenic diabetes, study finds

A biomarker screening pathway that integrates C-peptide and islet autoantibodies may help identify diabetes patients who have monogenic forms of the disease, including maturity-onset diabetes of the young, according to a study in Diabetes Care. UK researchers found that the pathway had a positive predictive value of 20%, "suggesting a 1-in-5 pickup rate for monogenic diabetes, a 5.6-fold increase in probability over the background prevalence alone."

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