Experts ID more genetic locations linked to obesity | Bariatric surgery alters gut microbes that aid weight loss, study says | Environment has big effect on childhood obesity, studies show
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April 24, 2013
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Experts ID more genetic locations linked to obesity
Researchers have identified seven new genetic locations associated with obesity. Genetic mechanisms that trigger severe forms of obesity were nearly the same as those that cause milder weight gain. The results appear on the website of Nature Genetics. U.S. News & World Report/HealthDay News (4/7)
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Science & Research
Bariatric surgery alters gut microbes that aid weight loss, study says
Part of the way Roux-en-Y gastric bypass surgery helps people lose weight is to change the makeup of gut bacteria, according to data from an animal study at Massachusetts General Hospital and Harvard University. The study in the journal Science Translational Medicine found obese mice injected with gut bacteria from other mice that had had bariatric surgery also lost weight and fat, without the surgical intervention. Reuters (3/27)
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Environment has big effect on childhood obesity, studies show
A child's living environment has a bigger effect on obesity than genetics, physical activity or other weight-control factors, according to studies published in Pediatrics. The research suggests issues such as plate size, media, school schedules and sleep are on a long list of environmental factors that contribute to childhood obesity. ScientificAmerican.com (4/9)
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Carotid body activation may lead to insulin resistance
Insulin-induced carotid body activation may increase sympathoadrenal activity that leads to insulin resistance and hypertension, according to an animal study in the journal Diabetes. However, carotid sinus nerve resection was shown to prevent CB overactivation and diet-related insulin resistance and hypertension, researchers said. PhysiciansBriefing.com/HealthDay News (4/16)
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Higher hair cortisol levels linked to greater diabetes, CVD risk
Older patients in the highest quartile of hair cortisol levels had a higher risk of developing type 2 diabetes and cardiovascular disease compared with those in the lowest quartile, a study indicated. The results appear in the Journal of Clinical Endocrinology and Metabolism. Healio/Endocrine Today (4/17)
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Type 1 diabetes study looks at vitamin D metabolism, atherosclerosis
Low concentrations of vitamin D metabolites did not appear to increase the risk of subclinical atherosclerosis in patients with type 1 diabetes, researchers wrote in Diabetes Care. Lower concentrations were linked to a reduced prevalence and severity of coronary artery calcium in patients. PhysiciansBriefing.com/HealthDay News (4/12)
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Products & Innovation
Diabetes research gets closer to devices that mimic a pancreas
New medical research and engineering have made advances toward creating implantable devices that monitor blood-sugar levels and act as a pancreas for patients with diabetes, including Medtronic's insulin pump that stops pumping insulin when glucose levels become low and Animas' combined insulin pump and continuous glucose monitor. The Wall Street Journal (4/8)
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FDA grants Sun Pharma approval for generic diabetes drugs
Sun Pharmaceutical Industries announced that the FDA awarded tentative approvals for its generic versions of diabetes drugs Januvia and Glumetza. Business Standard (India) (4/17)
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Trends & Technology
BMI measure isn't accurate for some obesity risks, study finds
The body-mass index is not the only factor to consider when determining obesity and its health risks, say researchers at the Pacific Research Centre for the Prevention of Obesity and Non-communicable Diseases at Fiji School of Medicine. Their study found that Polynesians who had the same BMI as Melanesians had lower risks for high glucose or blood pressure, possibly because Polynesians tend to have more body muscle. The Wall Street Journal (4/12)
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Review examines shortcomings in diabetes trials
Seventy-five percent of diabetes trials focused primarily on therapies, while 10% focused on prevention, according to a review in Diabetologia. The global study found 63% of the interventions were drugs, while 12% were behavioral therapies. The core group of participants was 18 and younger in 4% of trials, according to the review. Yahoo/Asian News International (4/6)
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TRI News
Poll: Researchers who conducted a recent study in the U.K. have identified four new genetic markers for severe childhood obesity. What is the most intriguing development? 
VoteGenetic factors in childhood obesity that are different from those in adult obesity may require separate forms of treatment
VoteThe variability of how these genes interact with other factors, including lifestyle behaviors
VoteThe promise that these genetic variants in severe cases of childhood obesity hold for more common forms of weight gain
VoteThe possibility of even more genetic variants related to childhood obesity that have yet to be discovered
Poll: Recent studies have shown a potential link between disturbances to the gut microbiome and obesity. In which areas do you think researchers should primarily focus their efforts to learn more?
The use of antibiotics in infants and a potential correlation with developing obesity later in life  50.00%
The effects of disturbances to the microbiome in other diseases compared with those in obesity  25.00%
All of these areas are equally important for researchers to investigate  12.50%
Potential effects of bariatric surgery on the microbiome  12.50%
SmartQuote
To dare is to lose one's footing momentarily. To not dare is to lose oneself."
-- Søren Kierkegaard,
Danish philosopher and writer
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