Researchers analyzed data on more than 10.5 million hospitalizations involving patients who underwent major noncardiac surgery, with and without diabetes and at least 45 years of age, and found that 3.3% of those with diabetes experienced perioperative major adverse cardiovascular and cerebrovascular events, compared with 2.8% among those without diabetes. The findings in Diabetes Care revealed that uncontrolled diabetes is an independent risk factor for perioperative cardiac events.
Patients with type 1 diabetes taking multiple daily insulin injections who used continuous glucose monitoring spent less time with daytime and nocturnal hypoglycemia and had an improved hypoglycemia-related confidence in social situations, compared with those who used self-measurement, according to a study in Diabetes Technology & Therapeutics. Researchers used a cohort of 161 patients and found increased confidence in the ability to avoid serious problems related to hypoglycemia and take preventive action among those in the CGM group, compared with the self-measurement group.
Researchers found that patients with type 2 diabetes, hypertension and dyslipidemia who maintained a stable statin therapy did not experience a reduced systolic blood pressure level after taking acetyl-L-carnitine supplementation, compared with a significant drop among those on placebo. The findings in the Journal of the Endocrine Society, based on 229 patients older than 40, revealed no significant difference in lipid and metabolic profiles between the two groups and no change in renal parameters during treatment.
South Asians in the US have higher proportional mortality rates from atherosclerotic cardiovascular disease than other Asian groups and non-Hispanic whites, according to a scientific statement from the American Heart Association that was published in Circulation. Researchers evaluated current literature related to South Asian populations and found that although South Asians did not have any unique risk factors, most of the risk is attributed to a higher prevalence of known risk factors, such as those associated with insulin resistance.
The Healthcare Access and Quality index varied significantly across 195 countries, territories and subnational locations, from a high of 97.1 in Iceland to a low of 18.6 in the Central African Republic, according to a study in The Lancet. Researchers analyzed the Global Burden of Diseases, Injuries, and Risk Factors Study 2016 and found that "alongside initiatives to strengthen public health programs, the pursuit of universal health coverage hinges upon improving both access and quality worldwide, and thus requires adopting a more comprehensive view -- and subsequent provision -- of quality health care for all populations."
Dutch researchers found that pediatric prehospital triage tools, such as the Pediatric Trauma Triage Checklist, Trauma Scorecard, and various adaptations of different Field Triage Decision Scheme versions and portions, yielded only 49.1% to 87.3% sensitivity, short of the international standard of at least 95% sensitivity, and 41.7% to 84.8% specificity in determining severely injured children who require specialized trauma care. The findings were published in JAMA Surgery.
Fifty-nine percent of children with epilepsy followed for one year or more after diagnosis were seizure-free for at least a year, while 30% developed drug resistance and 12% had intermediate seizure outcomes, Norwegian researchers reported in Pediatrics. The findings also showed that those with a known epilepsy cause had a 48% drug resistance risk, compared with a 21% risk among those whose epilepsy had an unidentified cause.
Bio Products Laboratory's supplemental biologics license application for Coagadex, which is being developed as a prophylactic treatment for patients with hereditary factor X deficiency who are younger than 12, was accepted by the FDA. The application was backed by results from a late-stage prospective study of the candidate in which investigators rated it excellent for all study subjects.
Individuals with depression were prone to greater cognitive decline in older adulthood than those who didn't have depression, researchers reported in the journal Psychological Medicine. The findings, based on a systematic review of 34 studies involving more than 71,000 people, underscore the importance of treating depression, researcher Amber John said.
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