Scripps Research Institute scientists found that the enzyme YRSACT, which is known to play a role in decoding DNA, appears to increase platelet production in tests of animals, according to a study in the journal Proceedings of the National Academy of Sciences. Researchers say YRSACT works by boosting production of platelet-producing megakaryocytes, and the findings suggest a new drug target to treat thrombocytopenia.
Health officials in California reported in the journal Emerging Infectious Diseases that the state had 588 cases of travel-related Zika virus infection from November 2015 to September 2017, and 64% of the probable viremia cases involved people living in counties where Aedes mosquitoes have been found. Meanwhile, the National Institute of Allergy and Infectious Diseases has begun a trial of an experimental live attenuated Zika vaccine in 28 healthy volunteers.
A late-stage study in The New England Journal of Medicine found 83% of 40 adults with multidrug-resistant HIV-1 infection who were treated with ibalizumab, or Trogarzo, experienced reductions in viral load.
Methicillin-resistant Staphylococcus aureus colonization is associated with increased risk of subsequent infection during and after hospitalization, according to a study in the journal Clinical Infectious Diseases of Department of Veterans Affairs data for 985,626 hospital admissions. "Hospitalized patients who are colonized with MRSA, regardless of whether they were colonized on admission or acquired it during their inpatient stay, are at high risk for MRSA infection," VA epidemiology researcher Richard Nelson said.
Health officials in the Democratic Republic of Congo reported five new confirmed cases of Ebola virus infection among four health care workers and a former patient at a center in Mangina. World Health Organization Director-General Tedros Adhanom Ghebreyesus said cases have been confirmed in a total of seven health care workers.
Mustang Bio and St. Jude Children's Research Hospital will work together to develop an ex vivo lentiviral gene therapy for severe combined immunodeficiency, or "bubble boy" disease. The collaboration will focus on completing their Phase I/II clinical trials, one of which involves patients under the age of 2, with promising responses from eight patients who already received the treatment.
EKF Diagnostics Holdings and McKesson Medical-Surgical have entered a US distribution agreement for EKF's DiaSpect Tm reagent-free hemoglobin analyzer. The device will be offered under the McKesson Consult Hb brand.
Clinical laboratories could provide help in different models of home-based health care programs, such as performing laboratory testing, advising on pre-analytical factors, certifying operators, choosing and validating the appropriate devices, guiding integration of results into the electronic medical record, managing IT connectivity, maintaining appropriate quality control and quality assurance procedures, and performing regular reviews of standard operating procedures.
An RNA and DNA sequencing platform developed by investigators from the Icahn School of Medicine at Mount Sinai in New York helps determine the best drug therapies for patients with late-stage and drug-resistant multiple myeloma. Details of the methodology were published in the journal JCO Precision Oncology.
A multi-site Phase Ib clinical trial has been initiated by biotech firm OncoPep to assess the safety and tolerability of its experimental vaccine candidate PVX-410 to treat smoldering multiple myeloma. Two different combinations will be tested in about 20 patients, with the first consisting of PVX-410 plus Celgene's investigational histone deacetylase inhibitor citarinostat and the second a combination of PVX-410, citarinostat and lenalidomide.
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