Lab Sciences
Top stories summarized by our editors
11/17/2017

The chimeric antigen receptor T-cell therapy developed as a multiple myeloma treatment by bluebird bio and Celgene, known as bb2121, has received breakthrough status from the FDA and PRIME status from the European Medicines Agency. The early-stage trial for bb2121 is ongoing and scheduled for completion in December 2018.

11/16/2017

HIV infection rates in 31 European countries are rising among older patients, according to a study by the European Center for Disease Prevention and Control, but it's not clear if the findings reflect a true increase or are due to better diagnosis and data reporting. The researchers documented 54,102 new cases of HIV between 2004 and 2015 among people ages 50 and older, and diagnoses increased 2.1% annually on average over the study period.

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MD Magazine online
11/16/2017

Initial data from Fate Therapeutics' trial assessing the efficacy of its drug candidate FATE-NK100 as a treatment for relapsed/refractory acute myelogenous leukemia were reported at the annual meeting of the Society for Immunotherapy of Cancer. Data showed members of each of the trial cohorts experienced anti-leukemic activity when treated with the agent.

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Reuters
11/16/2017

The first clinical trial site has been activated for Trovagene's Phase Ib/II acute myeloid leukemia trial to evaluate its lead candidate PCM-075. The trial will do enrollments for relapsed/refractory AML patients who have received no more than three previous treatments.

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Reuters
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AML, Trovagene, Trovagene
11/15/2017

The number of confirmed cases of dengue in India has reached 8,063, with 4,188 of those located in Delhi. Indian health officials also reported that the number of recorded cases of malaria as of Saturday stands at 1,106, while the number of chikungunya cases has reached 855.

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dengue, Malaria, India
11/15/2017

A distribution deal has been completed between Sysmex Asia Pacific and Genedrive for marketing rights to the latter's HCV ID kit and PCR platform for the Asia Pacific region. The partners plan to pursue regulatory approvals in a number of Asian countries for the assay.

11/15/2017

Aidan Hooper of Edmond, Okla., died in an accident when he was 8 years old. Aidan, whose donated heart valves gave lives to two young girls, will be honored as a tissue donor in the 2018 Tournament of Roses Parade.

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Tournament of Roses Parade
11/15/2017

A study evaluating wait-listing for 1,057 patients who were referred for kidney transplant evaluation found African-American patients were less likely than white patients to be wait-listed for transplant, and wait-listing was positively associated with income, transplant knowledge and having a live donor. Wait-listing was negatively associated with factors including age, comorbidities, being on dialysis and low socioeconomic status, researchers reported at the American Society of Nephrology annual meeting.

11/15/2017

A review in the journal Hepatology found that patients coinfected with hepatitis C virus and HIV experienced sustained virologic response (SVR) at similar rates after treatment with direct-acting antiviral therapies as patients infected with HCV alone. In contrast, coinfected patients assigned to interferon-based treatment were less likely to achieve SVR than monoinfected patients.

11/15/2017

Seasonal malaria chemoprevention, an older process that involves providing patients with a monthly combination dose of antimalarial drugs during the rainy season, was found to reduce the prevalence of malaria in West African children by up to 84%, according to data reported at a meeting of the American Society of Tropical Medicine and Hygiene. Seasonal malaria chemoprevention involves combining three drugs, sulphadoxine, pyrimethamine and amodiaquine, which will not negate the efficacy of the malaria drug artemisinin once that is taken.

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Nature (free content)