The National Institute of Allergy and Infectious Diseases is starting the first large US clinical trial to follow HIV-positive recipients of kidneys from HIV-positive donors to identify potential complications during and after surgery. The HOPE in Action Multicenter Kidney Study will involve 80 HIV-positive donors and 80 HIV-negative control donors, and the recipients will be followed for up to four years.
An experimental vaccine could be deployed by the World Health Organization in the Democratic Republic of Congo to prevent the spread of the Ebola virus. "We are very concerned and planning for all scenarios, including the worst-case scenario," WHO Deputy Secretary-General Peter Salama said.
The Peruvian health ministry announced a national epidemiological alert over reports of 19 suspected cases of Guillain-Barre syndrome, which has been tied to Zika virus infections.
Researchers from the Children's National Health System in Maryland have been observing 36 infants who were exposed to the Zika virus during pregnancy but did not manifest any abnormalities in prenatal or postnatal neuroimaging. At 6 months, the babies' neuromotor skills were similar to those of 68 infants unexposed to Zika, according to a study presented at the Pediatric Academic Societies annual meeting.
Democratic Republic of Congo health officials said on Tuesday that a new outbreak of Ebola has been confirmed with 21 patients manifesting symptoms of hemorrhagic fever and 17 dying in the affected area, a village in the northwest of the country.
Laboratories should specify the type of assay -- whether HPV DNA tests or HPV mRNA tests -- used in HPV screening of patients who have had one previous high-risk HPV-positive result, as well as those who have had at least two hrHPV-positive results, because it could affect patient follow-up, researchers found. The authors said they hope their findings "will start conversations between gynecologists and pathologists to be sure the HPV DNA test is used for primary screening to identify those at potential long-term risk."
A group of international researchers used mouse models to study the role of the Y chromosome gene UTY in protecting against the development of acute myeloid leukemia. The findings were reported online in the journal Nature Genetics.
The Clarity Clostridium difficile toxins A/B assay by Singulex outperformed other currently used diagnostic tests by rapidly detecting toxins at 100 times lower concentrations, a study found. Singulex expects FDA registration for the test by the end of the year.
A study in the journal PLOS Pathogens estimated that 84% of cases of dengue fever are the result of transmission from asymptomatic individuals. Researchers from the University of Notre Dame employed mathematical modeling based on demographics and disease characteristics and also found that 1% of transmissions are attributable to people whose infections have been clinically detected.
Research seeking to determine why some patients with relapsed/refractory chronic lymphocytic leukemia do not respond to chimeric antigen receptor T-cell therapy has yielded data that may give drug developers and scientists a clue, according to findings published in the journal Nature Medicine. "Our biomarker, which is defined as CD27-positive, CD45RO-negative CD8+ T cells in pre-manufactured T cells, may help in patient selection," said senior study author Joseph Melenhorst.