Obese children and adolescents with hyperinsulinemia and/or impaired fasting glucose or impaired glucose tolerance who took metformin daily for six months attained significant reductions in BMI compared with those in the placebo group, a study found. Improvements in fasting glucose, alanine aminotransferase and adiponectin-to-leptin ratio were also seen in metformin-treated patients, researchers noted. The findings appear in the Journal of Clinical Endocrinology & Metabolism.