Sequestration will hit hard in public health and medical research, both of which have been restricted by years of underfunding or retrenchment. "These cuts are going to have a real impact," Washington state Health Secretary Mary Selecky said. "In the next six to eight weeks, we're going to have to say we're closed on Fridays or we can't provide this or that service anymore." Researchers who depend on NIH grants have also expressed concern that their work will have to be scaled back.