A new study concludes that hormone replacement therapy not only is no defense against dementia in women 65 and older, but that taking estrogen alone may even add to their risk of getting the disease. Researchers report in the Journal of the American Medical Association that Premarin, Wyeth's version of an estrogen drug, may increase the risk of dementia in women over 65 who had hysterectomies and who took the estrogen-only pill regularly. Earlier studies said estrogen in combination with progestin had the same negative result.

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