Patients treated with Tenacrine, a generic version of tacrolimus, after their first kidney transplant had a greater likelihood of rejecting the organ than did those treated with Prograf, the nongeneric version, according to the findings of a three-year study. About twice as many patients on the generic version developed acute rejection. Children younger than 10 years and with heart disease had a greater probability of rejecting the organ regardless of which drug they were given.

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