U.S. researchers working with sedentary mice found that two drugs can activate a process that increases athletic endurance, raising hopes for a workout in a pill that may benefit people who are too weak to exercise or those who have muscle disorders. A compound known as AICAR allowed the animals to run on a treadmill 44% longer after four weeks of treatment. GlaxoSmithKline's GW1516 boosted endurance levels by 75% but had to be used in conjunction with training to have any effect.

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