A study backed by Novartis showed that a pill containing two blood-pressure medicines -- benazepril, an angiotensin-converting enzyme inhibitor, and amlodipine, a calcium-channel blocker -- caused 20% fewer serious cardiovascular problems and death than a combination pill consisting benazepril and the diuretic hydrochlorothiazide. The finding calls into question guidelines recommending a diuretic-based strategy for managing hypertension, researchers said.

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