Researchers using FDG-PET found that the macrophage-rich plaque in the vessel walls of rabbits on a high-cholesterol diet was more enhanced compared with rabbits on a normal diet two hours after they were injected with NanoScan's contrast agent N1177. The enhancement intensity resulting from N1177 injection also correlated with the FDG uptake on PET/CT and macrophage density on immunohistology. The findings indicate that N1177 can be used to pinpoint high-risk atherosclerotic plaque using CT.

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