A Dutch review of literature on the accuracy and clinical value of SPECT and PET in detecting bone and joint infections showed that SPECT/CT with Indium-labeled white blood cells combined with 99mTc-methylene diphosphonate or 99mTc-sulfur colloid had the highest accuracy rate of 95% in diagnosing the infections. The review also found that FDG-PET had a sensitivity and specificity of more than 95% in diagnosing osteomyelitis and that localization of the disease could be enhanced with the addition of CT.

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